Jianing Fu, PhD

  • Assistant Professor of Medical Sciences (in Medicine)

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Overview

Dr. Jianing Fu is an Assistant Professor in the Department of Medicine and a principal investigator at the Columbia Center for Translational Immunology (CCTI). Dr. Fu obtained her BS degree in Pharmaceutical Sciences and MS degree in Chemical Biology from Peking University (China) and received her PhD in Cancer Biology and Immunology from University of South Florida and H. Lee Moffitt Cancer Center. She did a Curricular Practical Training at Medical University of South Carolina to complete her doctoral education. Dr. Fu joined Columbia University in May 2015 to start her postdoctoral training and later took the lead on several projects related to human organ transplantation under the roles of Associate Research Scientist and Instructor.

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine)

Languages

  • Chinese
  • English

Gender

  • Female

Credentials & Experience

Education & Training

  • BS, 2008 Pharmaceutical Sciences, Peking University
  • MS, 2010 Chemical Biology, Peking University
  • Graduate Certificate, 2013 Clinical Investigation, University of South Florida
  • PhD, 2015 Cancer Biology (and Immunology), University of South Florida

Honors & Awards

  • 2022: USERN Prize Laureate in Biological Sciences, USERN (Universal Scientific Education and Research Network)
  • 2020/2021/2022: Nelson Family Transplant Innovation Awards, CUMC
  • 2022: Community of Transplant Scientists (COTS) registration bursary
  • 2020: The Federation of Clinical Immunology Societies (FOCIS) Travel Award
  • 2020: FCE (FOCIS Center of Excellence) Travel Award
  • 2020: Top scored abstract, The Transplantation Society (TTS)
  • 2019: Discovery Award, Department of Defense
  • 2019: Transplant Forum Scholar Award, CUMC
  • 2019: Medicine Grand Rounds, Fellow Research Presentation Award, CUMC
  • 2018: Outstanding Oral Presentation Award, CCTI Research Day
  • 2017/2018: International Transplantation Science Mentee-Mentor Awards, TTS
  • 2017 Best Abstract, The Intestinal Rehabilitation & Transplant Association (IRTA)
  • 2016: Young Investigator Scientific Award, TTS
  • 2015: Outstanding Thesis & Dissertation Award, University of South Florida (USF)
  • 2012/2014: Abstract Achievement Awards, American Society of Hematology
  • 2012/2013: Cancer Biology Travel Awards, USF
  • 2012: Cancer Biology Student Organization Community Service Award, USF
  • 2008 Excellent Volunteer in Beijing Olympic Games (Anti-doping Agency)
  • 2006/2007/2008: Scholarships for Excellent Medical Students, Peking University
  • 2023: The Federation of Clinical Immunology Societies (FOCIS) Travel Award

Research

Dr. Fu’s laboratory is conducting translational research on decoding the graft-versus-host (GvH) and host-versus-graft (HvG) alloreactivity after human intestinal transplantation and lung transplantation. Her research also extends in investigating the phenotype and function of gut and lung hematopoietic stem cells and progenitors, with the ultimate goal of eliminating graft rejection by inducing long persistent blood mixed chimerism. Dr. Fu has established long term multidisciplinary collaboration with transplant surgeons, adult and pediatric physicians, pathologists, bioinformatic scientists and translational immunologists to perform cutting edge human transplantation studies.

Grants

  • 2022-2024 Nelson Faculty Development Award, CUMC.
    PI: Jianing Fu, PhD
    Functional profile, migration pattern and microenvironment of human hematopoietic stem and progenitor cells residing in ectopic organ sites under physiological and inflammatory conditions
  • 2021-2024 R21, NIH/NIAID, AI166069-01.
    PI: Jianing Fu, PhD
    Immune profiling of gamma delta T cells after human intestinal transplantation.
  • 2021-2023 Nelson Faculty Development Award, CUMC.
    PI: Jianing Fu, PhD
    Chimerism and immune repertoire of human gamma delta T cells after human lung transplantation.
  • 2020-2022 Discovery Award, DoD, W81XWH-20-1-0159.
    PI: Jianing Fu, PhD
    Single Cell Immune Profiling of Alloreactive T cells Locally and Systemically in Patients Receiving Intestinal Transplantation.
  • 2020-2021 Nelson Faculty Development Award, CUMC.
    PI: Jianing Fu, PhD
    Phenotypic and clonal tracking of human gamma delta T cells after human intestinal transplantation

Selected Publications

  1. Fu J*, Wang Z, Martinez M, Jiao W, Frangaj K, Jones R, Guo X, Zhang Y, Kuo W-I, Ko H, Iuga A, Obradovic A, Bay Muntnich C, Rogers K, Zuber J, Ma W, Miron M, Farber D, Kato T, Shen Y, Sykes M*. Heterogeneity and Plasticity of Alloreactive T Cells in Human Intestinal Allografts: New Insights into Tissue Residency and Immune Tolerance after Transplantation. Journal of Experimental Medicine. 2024. 221 (1): e20230930. (*Co-corresponding author)
  2. Wu Y, Zuber J and Fu J*. Editorial: Immunogenomics of Solid Organ and Hematopoietic Stem Cell Transplantation. Frontiers in Immunology. 2022, 13:878314. (*Corresponding author)
  3. Fu J, Sykes M. Emerging Concepts of Tissue-Resident Memory T cells in Transplantation. Transplantation. 2022 Jun 1;106(6):1132-1142.
  4. Obradovic A, Shen Y, Sykes M, Fu J*. Integrated Analysis Toolset for Defining and Tracking Alloreactive T-cell Clones After Human Solid Organ and Hematopoietic Stem Cell Transplantation. Software Impacts. 2021 (10) 100142 (*Corresponding author)
  5. Fu J#, Khosravi-Maharlooei M, Sykes M. High throughput human T cell receptor sequencing: a new window into repertoire establishment and alloreactivity. Frontiers in Immunology. 2021, 12:777756. #Co-first author.
  6. Fu J, Zuber J, Shonts B, Obradovic A, Wang Z, Frangaj K, Meng W, Rosenfeld A, Waffarn E, Liou P, Lau S-p, Savage T, Yang S, Rogers K, Danzl Nichole, Ravella S, Satwani P, Iuga A, Ho S-h, Griesemer A, Shen Y, Luning-Prak E, Martinez M, Kato T, Sykes M. Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation. Journal of Clinical Investigation. 2021 Apr 15;131(8):e141698.
  7. Fu J, Zuber J, Martinez M, Shonts B, Obradovic A, Wang H, Lau S-p, Xia A, Waffarn E, Frangaj K, Savage T, Simpson T, Yang S, Guo X, Miron M, Senda T, Rogers K, Rahman A, Ho S-h, Shen Y, Griesemer A, Farber D, Kato T, Sykes M. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that are Maintained by a Circulating Pool. Cell Stem Cell. 2019 Feb 7;24(2):227-239.e8. (Commentary: “We Could Use More Tolerance: Role of Intestinal-Allograft- Derived Human Stem Cells”.)
  8. Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, and Yu X-Z. T-bet promotes acute graft-versus-host disease by regulating recipient hematopoietic cells in mice. J Immunol. 2016 Apr 1; 196 (7): 3168-3179. Cover Article.
  9. Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald D, Anasetti C, and Yu X-Z. T-bet is critical for the development of acute graft-versus-host disease through controlling T-cell differentiation and function. J Immunol. 2015 Jan 1;194(1):388-97.
  10. Fu J, Heinrichs J, Yu X. Helper T-cell Differentiation in Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Arch Immunol Ther Exp. 2014 Aug; 62(4): 277-301
  11. Crosby K, Long K and Fu J. Chimerism-Mediated Tolerance in Intestinal Transplantation. Gastroenterology Clinics of North America. 2024. Epub ahead of print. doi:10.1016/j.gtc.2023.12.009
  12. Suek N, Young T and Fu J. Immune Cell Profiling in Intestinal Transplantation. Human Immunology. 2024 May 18:110808. doi: 10.1016/j.humimm.2024.110808. Epub ahead of print.

For a complete list of publications, please visit PubMed.gov